In renal failure, metabolic acidosis is due to?
Correct Answer: Decreased excretion of ammonia
Description: Metabolic acidosis can occur because of increased endogenous acid production (lactate and ketoacids) loss of bicarbonate accumulation of endogenous acid (as seen in renal failure) -Ammonia is excreted out linked to H+ as ammonium ion and for every positive charge lost, chloride is lost to maintain electroneutrality. -In case of a renal failure both ammonia and protons are retained leading to high anion gap acidosis as the positive charges in the body are increased.
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