In Rabies, the characterstic pathological manifestation is –
**Core Concept**
Rabies is a viral disease caused by a lyssavirus that affects the central nervous system (CNS), leading to inflammation and degeneration of neurons. The characteristic pathological manifestation in rabies is a result of the virus's ability to infect and replicate within the CNS.
**Why the Correct Answer is Right**
The correct answer is associated with the formation of Negri bodies, which are eosinophilic, rounded inclusions found within the cytoplasm of infected neurons. These inclusions are composed of viral nucleocapsid protein and are a hallmark of rabies infection. The presence of Negri bodies is a diagnostic feature of rabies and can be identified through histopathological examination of brain tissue. The virus targets the hippocampus, cerebellum, and brainstem, leading to inflammation and degeneration of neurons, which ultimately results in the characteristic pathological manifestation of rabies.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it does not describe a characteristic pathological manifestation of rabies.
**Option B:** This option is incorrect because it is not a specific pathological feature associated with rabies infection.
**Option C:** This option is incorrect because it describes a different type of viral infection that affects the CNS.
**Clinical Pearl / High-Yield Fact**
The presence of Negri bodies in brain tissue is a diagnostic feature of rabies and can be identified through histopathological examination. This is an important clinical correlation for students to remember when diagnosing patients suspected of having rabies.
**Correct Answer: C. Formation of Negri bodies in infected neurons.**