In patients with cirrhosis of the liver the site of obstruction in the poal system is in the :
Correct Answer: Sinusoids
Description: Answer is D (Sinusoids): 'When cirrhosis is complicated by poal hypeension the increased resistance is usually sinusoidar-Harrison's 15th/1759 Poal hypeension (> 10 mm Hg: Normal poal pressure = 5 to 10 mmHg) most commonly results from increased resistance to poal blood flow. Increased resistance can occur at three levels: Presinusoidal Anatomically outside the liver eg. Poal vein thrombosis Within the liver but proximal to sinusoids eg. Schistosomiasis Sinusoidal Cirrhosis When cirrhosis is complicated by poal hypeension, the increased resistance is usually sinusoidal Post sinusoidal Outside liver, at level of hepatic veins - Budd chiarri syndrome In the inferior vena cava - Thrombosis In the liver but distal to sinusoid - Venoocclusive disease Remember : Cirrhosis is the most common cause of poal hypeension in the United States.Q Poal vein obstruction is the second most common cause. Q
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