Pathology In patients with Chronic Myeloid Leukemia A ABL gene on Chr. 22 is trans-located to BCR gene on Chr.9 B The fusion gene bcr-abl forms a protein with tyrosine kinase activity C Splenomegaly is unusual D Philadelphia chromosome positive patients respond poorly to Imatinib 💡 Explanation In patients with Chronic Myeloid Leukemia ✓ Correct Answer: B. The fusion gene bcr-abl forms a protein with tyrosine kinase activity