In patients with Chronic Myeloid Leukemia

A. ABL gene on Chr. 22 is trans-located to BCR gene on Chr.9

B. The fusion gene bcr-abl forms a protein with tyrosine kinase activity

C. Splenomegaly is unusual

D. Philadelphia chromosome positive patients respond poorly to Imatinib

Correct Answer: The fusion gene bcr-abl forms a protein with tyrosine kinase activity

Description: Ans. (b) The fusion gene bcr-abl forms a protein with tyrosine kinase activity(Ref: Robbins 9th/pg 616-618)a. FALSE, as ABL gene is on chr9q while BCR is on chr22qb. The fusion gene bcr-abl forms a protein with tyrosine kinase activity: TRUEc. FALSE; Massive splenomegaly is a feature of CMLd. FALSE; as response to Imatinib is good in patients with Philadelphia chromosome +ve

Category: Pathology

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