Physiology In Myasthenia gravis, the fundamental defect at the neuromuscular junction is: A Deficiency of ACh (Acetylcholine) B Defect in release of ACh C Failure of ACh to attach to the postsynaptic receptor D Impeded presynaptic release of ACh 💡 Explanation In Myasthenia gravis, the fundamental defect at the neuromuscular junction is: ✓ Correct Answer: C. Failure of ACh to attach to the postsynaptic receptor