**Question:** In Henoch Scholien purpura, there is all except:

A. Hemolytic anemia
B. Vasculitis
C. Pernicious anemia
D. Thrombocytopenia

**Core Concept:** Henoch-Schönlein Purpura (HSP) is a systemic vasculitis characterized by the presence of immune complexes in small and medium-sized blood vessels, most commonly affecting children. Clinical features include mucocutaneous purpura, abdominal pain, joint pain, and renal involvement.

**Why the Correct Answer is Right:**

In Henoch-Schönlein Purpura, the correct answer refers to the absence of a specific condition that is typically not present in this disease. In this case, the correct answer is:

**Option C: Pernicious Anemia**

Pernicious anemia is a distinct clinical entity characterized by chronic refractory anemia due to vitamin B12 deficiency, often associated with atrophic gastritis and absence of intrinsic factor production in the stomach. In contrast to HSP, pernicious anemia is not a vasculitis and does not involve immune complexes.

**Why Each Wrong Option is Incorrect:**

The incorrect options represent clinical entities that are either directly related to HSP or exhibit similar symptoms but are distinctive from HSP. Let's discuss these options:

**Option A: Hemolytic Anemia**
Hemolytic anemia is a type of anemia characterized by the breakdown (hemolysis) of red blood cells, leading to a decrease in red blood cell mass and a rise in bilirubin levels. While HSP can present with anemia, it is not solely due to hemolysis but also involves vasculitis.

**Option B: Vasculitis**
Vasculitis is a group of disorders characterized by inflammation of blood vessels, often leading to tissue ischemia and necrosis. HSP is a specific type of vasculitis, specifically affecting small and medium-sized blood vessels.

**Option D: Thrombocytopenia**
Thrombocytopenia refers to a decrease in platelets, which is commonly observed in HSP but is not the disease itself.

**Clinical Pearl:**

Understanding the distinction between Henoch-Schönlein Purpura and the wrong options is crucial in differentiating these entities and arriving at an accurate diagnosis. While all three incorrect options (hemolytic anemia, vasculitis, thrombocytopenia) can be seen in HSP, the correct answer (Pernicious Anemia) is a separate clinical entity unrelated to HSP and is caused by vitamin B12 deficiency.