**Question:** In hemochromatosis iron not deposited in -

A. Liver
B. Heart
C. Pancreas
D. Brain

**Core Concept:** Hemochromatosis is a genetic disorder characterized by excessive iron absorption from the gastrointestinal tract, leading to iron overload in various organs.

**Why the Correct Answer is Right:** In hemochromatosis, the body has a genetic defect in iron regulation, causing increased intestinal absorption of iron. This iron is deposited in tissues like liver, heart, and pancreas. However, the brain is spared because it has a high energy demand but has limited iron storage capacity, and thus requires ongoing iron replenishment from the circulation. As a result, iron overload in the brain is less common in hemochromatosis compared to other organs.

**Why Each Wrong Option is Incorrect:**

A. Liver: Iron overload in the liver is a common feature of hemochromatosis as the liver has abundant iron storage capacity.
B. Heart: Iron overload in the heart is also a common feature, as the heart relies on iron for efficient functioning.
C. Pancreas: Iron overload in the pancreas is also a common feature, as the pancreas also requires iron for its functions.

**Clinical Pearl:** Hemochromatosis should be suspected in patients presenting with joint pain, fatigue, diabetes, or cirrhosis, as these are common manifestations of iron overload in affected organs.

**Correct Answer:** D. Brain (Iron is not deposited in the brain in hemochromatosis)