In haemolytic glaucoma the mechanisms are all except –
**Core Concept**
Haemolytic glaucoma is a rare condition characterized by the obstruction of the anterior chamber aqueous outflow due to the presence of red blood cells and their breakdown products, leading to increased intraocular pressure (IOP). This condition is often associated with conditions that cause excessive red blood cell destruction, such as hemoglobinopathies.
**Why the Correct Answer is Right**
The correct answer is related to the pathophysiology of haemolytic glaucoma. The main mechanism involves the breakdown of red blood cells, which releases hemoglobin and its derivatives into the aqueous humor. This leads to the formation of hemoglobin aggregates, which can clog the trabecular meshwork and reduce aqueous outflow. The increased IOP can cause optic nerve damage and vision loss.
**Why Each Wrong Option is Incorrect**
* **Option A:** This option is incorrect because hemolysis and the resulting increase in IOP are the primary mechanisms in haemolytic glaucoma. While inflammation may be a secondary consequence, it is not a primary mechanism.
* **Option B:** This option is incorrect because the breakdown of red blood cells is the key event leading to the obstruction of aqueous outflow in haemolytic glaucoma. While the release of hemoglobin and its derivatives is a critical step, it is not the primary mechanism.
* **Option C:** This option is incorrect because while inflammation may be a secondary consequence of haemolytic glaucoma, it is not a primary mechanism of the condition.
**Clinical Pearl / High-Yield Fact**
Haemolytic glaucoma is often associated with conditions that cause excessive red blood cell destruction, such as hemoglobinopathies like sickle cell disease. It is essential to consider this condition in patients with unexplained increased IOP and a history of hemoglobinopathies.
**Correct Answer:** D