In G6PD deficiency, which cells are more prone for hemolysis?
**Core Concept:** G6PD deficiency is a genetic disorder affecting the enzyme glucose-6-phosphate dehydrogenase (G6PD), which plays a crucial role in the defense against oxidative stress in red blood cells (RBCs). RBCs are more prone to hemolysis in cases of G6PD deficiency due to their lack of antioxidant protection.
**Why the Correct Answer is Right:** In G6PD deficiency, the body lacks sufficient G6PD enzyme, which results in inadequate protection against oxidative stress. Oxidative stress occurs when there is an imbalance between the production of reactive oxygen species (ROS) and the body's antioxidant defense mechanisms. When ROS overwhelms the antioxidant defenses, it leads to hemolysis (destruction) of RBCs.
**Why Each Wrong Option is Incorrect:**
A. Kidney cells and liver cells are not prone to hemolysis in G6PD deficiency, as they have a robust antioxidant defense system and are not directly affected by oxidative stress in RBCs.
B. While platelets are also affected by oxidative stress, they are not the primary cells prone to hemolysis in G6PD deficiency. RBCs are the cells primarily affected due to their lack of antioxidant enzymes.
C. Similar to B, lymphocytes are affected by oxidative stress, but they are not the primary cells prone to hemolysis in G6PD deficiency. RBCs are the cells mostly affected because of their deficiency in antioxidant enzymes.
D. Neurons are not involved in hemolysis in G6PD deficiency. The primary cells affected are RBCs due to their lack of antioxidant enzymes, such as G6PD.
**Clinical Pearl:** G6PD deficiency is a common cause of hemolytic anemia, particularly in Mediterranean, Asian, and African populations. It is essential for medical students and practitioners to recognize this condition to avoid potential complications when prescribing medications like primaquine, which can trigger an acute hemolytic crisis in G6PD deficient individuals.
**Correct Answer:** B. Platelets
In G6PD deficiency, platelets are affected by oxidative stress, but they are not the primary cells prone to hemolysis. RBCs are the cells mostly affected because of their deficiency in antioxidant enzymes like G6PD.