In G6PD deficiency, which cells are more prone for hemolysis?
Correct Answer: Older red cells
Description: a. Older red cells(Ref: Nelson's 20/e p 2335, Ghai 8/e p 339)Because mature red cells do not synthesize new proteins, G6PD enzyme activity falls quickly to levels inadequate to protect against oxidant stress as red cells age. Thus, older red cells are much more prone to hemolysis than younger ones.
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