In G6PD deficiency patient, hemolysis is due to decrease in
**Core Concept**
G6PD (Glucose-6-phosphate dehydrogenase) deficiency is an X-linked recessive disorder that affects the enzyme G6PD, which protects red blood cells from oxidative stress. This deficiency leads to hemolysis in response to certain triggers, such as medications, infections, or exposure to certain foods.
**Why the Correct Answer is Right**
In G6PD deficiency, the enzyme's primary function is to maintain the levels of NADPH in the pentose phosphate pathway. NADPH is crucial for protecting red blood cells from oxidative damage by maintaining the reduced state of glutathione. When G6PD is deficient, the levels of NADPH decrease, and the red blood cells become more susceptible to hemolysis.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is not relevant to G6PD deficiency.
**Option B:** This is incorrect because G6PD deficiency does not directly affect the levels of ATP in red blood cells.
**Option C:** This option is not directly related to the pathophysiology of G6PD deficiency.
**Clinical Pearl / High-Yield Fact**
G6PD deficiency is an X-linked recessive disorder, which means it primarily affects males. However, females can be carriers and may exhibit mild symptoms.
**Correct Answer:** C. Reduced NADPH levels.