Pharmacology In drug metabolism, hepatic cytochrome P-450 system is responsible for: A Phase I reactions (hydrolysis, oxidation, reduction etc.) only B Phase II reactions (conjugation, synthesis etc.) only C Both phase I and II reactions D Converting hydrophilic metabolites to lipophilic metabolites 💡 Explanation In drug metabolism, hepatic cytochrome P-450 system is responsible for: ✓ Correct Answer: A. Phase I reactions (hydrolysis, oxidation, reduction etc.) only