In chronic arsenic poisoning, greatest amount found in –
**Core Concept**
Chronic arsenic poisoning occurs when arsenic builds up in the body over time, leading to various systemic effects. Arsenic is a potent toxin that affects multiple organ systems, including the skin, liver, kidneys, and nervous system.
**Why the Correct Answer is Right**
In chronic arsenic poisoning, arsenic is primarily stored in keratin-containing tissues, such as skin, hair, and nails. This is because arsenic binds to keratin, a protein that provides structure and strength to skin, hair, and nails. As a result, the highest concentrations of arsenic are typically found in these tissues. This is why arsenic poisoning often manifests with skin lesions, hair loss, and nail changes.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because arsenic is not primarily stored in the liver, although it can cause liver damage and dysfunction.
**Option B:** This option is incorrect because arsenic is not primarily stored in the kidneys, although it can cause kidney damage and dysfunction.
**Option C:** This option is incorrect because arsenic is not primarily stored in the nervous system, although it can cause neurological effects such as peripheral neuropathy.
**Clinical Pearl / High-Yield Fact**
In chronic arsenic poisoning, the skin, hair, and nails are often the most affected tissues, and a thorough examination of these areas can provide important clues to diagnosis.
**Correct Answer: C. Skin, hair, and nails.**