In belladona poisoning, antidote is:
**Core Concept**
Belladonna poisoning is caused by the anticholinergic effects of the alkaloids atropine and scopolamine, leading to symptoms such as mydriasis, tachycardia, and delirium. The primary goal in managing belladonna poisoning is to reverse these anticholinergic effects.
**Why the Correct Answer is Right**
Physostigmine, a reversible cholinesterase inhibitor, is the specific antidote for belladonna poisoning. It works by increasing the concentration of acetylcholine in the synaptic cleft, thereby overcoming the blockade caused by atropine and scopolamine. This results in the reversal of anticholinergic symptoms and restoration of normal cholinergic function.
**Why Each Wrong Option is Incorrect**
**Option A:** Atropine is not the antidote for belladonna poisoning, as it is the primary alkaloid responsible for the anticholinergic effects. Using atropine would further exacerbate the poisoning.
**Option B:** Gastric lavage and activated charcoal may be used to manage belladonna poisoning, but they are not specific antidotes and do not address the underlying anticholinergic effects.
**Option C:** Dopamine and other sympathomimetics may be used to manage cardiovascular symptoms, but they do not address the anticholinergic effects and are not specific antidotes for belladonna poisoning.
**Clinical Pearl / High-Yield Fact**
Physostigmine is a specific antidote for belladonna poisoning, but it should be used with caution due to its potential to cause bradycardia and seizures, especially in high doses.
**Correct Answer: C. Physostigmine**