Pathology In apoptosis, Apaf-1 is activated by release of which of the following substances from the mitochondria? A Bcl-2 B Bax C Bcl - XL D Cytochrome C 💡 Explanation In apoptosis, Apaf-1 is activated by release of which of the following substances from the mitochondria? ✓ Correct Answer: D. Cytochrome C