Pathology In apoptosis, Apaf-1 is activated by release of which of the following substances from the mitochondria ? A Bel - 2 B Bax C Bcl - XL D Cytochrome C 💡 Explanation In apoptosis, Apaf-1 is activated by release of which of the following substances from the mitochondria ? ✓ Correct Answer: D. Cytochrome C