In Addison’s disease drug to be given is:
**Core Concept**
Addison's disease is a rare endocrine disorder characterized by the insufficient production of cortisol and aldosterone hormones by the adrenal glands. The primary goal of treatment is to replace these deficient hormones and manage the associated symptoms.
**Why the Correct Answer is Right**
Glucocorticoids like prednisone are essential in managing Addison's disease. Prednisone is a synthetic corticosteroid with a similar structure to cortisol, which allows it to be converted to cortisol in the liver. This conversion enables prednisone to mimic the effects of cortisol, alleviating symptoms such as fatigue, weight loss, and hypotension. Additionally, prednisone has anti-inflammatory properties, which are beneficial in managing secondary infections and inflammation associated with Addison's disease.
**Why Each Wrong Option is Incorrect**
**Option A:** Hydrocortisone is indeed a glucocorticoid, but it is typically used as a short-term replacement in acute adrenal insufficiency or during surgery. It is not the primary long-term treatment for Addison's disease.
**Option B:** Fludrocortisone is an aldosterone analog used to replace aldosterone in Addison's disease, but it is not a glucocorticoid and does not address the cortisol deficiency.
**Option C:** Dexamethasone is a synthetic glucocorticoid with a longer duration of action, but it is not typically used as first-line treatment for Addison's disease due to its long half-life and potential for causing iatrogenic Cushing's syndrome.
**Clinical Pearl / High-Yield Fact**
When prescribing glucocorticoids for Addison's disease, it is essential to instruct patients on the importance of taking their medication at the same time each day, as missed doses can lead to acute adrenal crisis.
**Correct Answer:** C. Prednisone