**Core Concept**
Acute pancreatitis is a sudden inflammation of the pancreas, leading to activation of digestive enzymes within the pancreas and subsequent tissue damage. This condition can result from various factors, including gallstones, excessive alcohol consumption, and certain medications.

**Why the Correct Answer is Right**
In acute pancreatitis, several pathophysiological changes occur, including the activation of pancreatic enzymes, release of pro-inflammatory cytokines, and activation of the coagulation cascade. The correct answer represents a condition that is not typically seen in acute pancreatitis.

**Why Each Wrong Option is Incorrect**
**Option A:** Elevated lipase levels are commonly seen in acute pancreatitis, as lipase is one of the enzymes released by the pancreas in response to inflammation.

**Option B:** Hyperglycemia can occur in acute pancreatitis due to the release of glucagon and other hormones that stimulate glycogenolysis and gluconeogenesis.

**Option C:** Leukocytosis, which is an increase in white blood cell count, is often seen in acute pancreatitis as a response to the inflammation and tissue damage.

**Clinical Pearl / High-Yield Fact**
A key feature of acute pancreatitis is the presence of elevated serum amylase and lipase levels, which can be used to diagnose the condition. However, it's essential to note that these enzymes can also be elevated in other conditions, such as salivary gland disease or intestinal obstruction.

**Correct Answer: D.**