Physiology In a demyelinating disease (e.g. multiple sclerosis), symptoms worsen with hot bath and improve with decreased temperature because: A Lower temperatures slow the gating kinetics of Na+ channels B AP duration increases with increased temperature C Activity of K+ channels is increased at lower temperatures D Inadequate recharging of the denuded axon at higher temperatures 💡 Explanation In a demyelinating disease (e.g. multiple sclerosis), symptoms worsen with hot bath and improve with decreased temperature because: ✓ Correct Answer: A. Lower temperatures slow the gating kinetics of Na+ channels