Dental In a cusp–embrasure relationship, the maxillary first premolar is most likely to articulate with which of the following mandibular teeth? A First premolar only. B First molar only. C Canine and first premolar. D First and second premolars. 💡 Explanation In a cusp–embrasure relationship, the maxillary first premolar is most likely to articulate with which of the following mandibular teeth? ✓ Correct Answer: D. First and second premolars.