Impaired function of Aquaporin results in

Correct Answer: Nephrogenic DI
Description: ADH acts V2 receptors on DCT casuing facultative reabsorption of water by inseing Aquaporin -2 channels into apical (luminal side ). Nephrogenic DI-defect in aquaporins BATER SYNDROME - Autosomal recessive Defect in"Na-K-2Cl cotranspoer, Cl channel & ROMK"in loop of Henle LIDDLE SYNDROME - Gain of function of epithelial Na channel (ENaC) Cystic fibrosis - CH-7 defect in CFTR gene - causing defect in transmembrane chloride ion regulation.
Category: Physiology
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