All of the following statements about immunosuppressants are true EXCEPT :
**Core Concept**
Immunosuppressants are a class of medications that inhibit the immune system, reducing the risk of organ rejection in transplant patients and modulating autoimmune diseases. They work by targeting various components of the immune response, including T cells, B cells, and inflammatory pathways.
**Why the Correct Answer is Right**
The correct answer will be the statement that does not accurately describe the mechanism or effect of immunosuppressants. Immunophilin ligands, such as cyclosporine and tacrolimus, inhibit calcineurin, which is necessary for T-cell activation and proliferation. Corticosteroids, like prednisolone, suppress inflammation by reducing the transcription of pro-inflammatory cytokines. Mycophenolate mofetil inhibits inosine monophosphate dehydrogenase (IMPDH), an enzyme crucial for T- and B-cell proliferation.
**Why Each Wrong Option is Incorrect**
**Option A:** This statement is true, as immunosuppressants are indeed used to prevent organ rejection in transplant patients.
**Option B:** This statement is also true, as corticosteroids are widely used to suppress inflammation and modulate the immune response.
**Option C:** This statement is true, as mycophenolate mofetil is a well-established immunosuppressant that inhibits T- and B-cell proliferation.
**Clinical Pearl / High-Yield Fact**
When choosing an immunosuppressant, clinicians must balance the benefits of reducing organ rejection and inflammation with the risks of increased susceptibility to infections and malignancies.
**Correct Answer: D.