Immunoglobulin having maxium molecular weight and is first to be synthesised in fetus?
**Core Concept**
Immunoglobulins, also known as antibodies, are proteins produced by B cells that play a crucial role in the immune system. They are classified into five classes: IgA, IgD, IgE, IgG, and IgM. The molecular weight of these immunoglobulins varies, with IgM having the highest molecular weight due to its pentameric structure.
**Why the Correct Answer is Right**
IgM is the first immunoglobulin to be synthesized in the fetus, and it has the highest molecular weight due to its pentameric structure. This is because IgM is composed of five Ig units linked together by a J-chain, resulting in a larger molecular weight compared to other immunoglobulins. The production of IgM is essential in the fetus as it provides protection against infections before the mother's IgG antibodies are transferred across the placenta.
**Why Each Wrong Option is Incorrect**
* **Option A:** IgA is primarily found in mucosal surfaces and has a molecular weight lower than IgM. It is not the first immunoglobulin to be synthesized in the fetus.
* **Option B:** IgD is primarily found on the surface of B cells and has a molecular weight similar to IgG. It is not the first immunoglobulin to be synthesized in the fetus.
* **Option C:** IgE is involved in allergic reactions and has a molecular weight similar to IgG. It is not the first immunoglobulin to be synthesized in the fetus.
**Clinical Pearl / High-Yield Fact**
IgM is the first immunoglobulin to be synthesized in the fetus, and its production is essential for providing protection against infections. This is a critical aspect of fetal immunology, and understanding the role of IgM in fetal development is essential for pediatricians and obstetricians.
**Correct Answer: C. IgM**