**Core Concept**
Whole cell pertussis vaccines, commonly used in the past, can cause a range of adverse reactions due to the presence of inactivated Bordetella pertussis bacteria. These reactions are often mild and self-limiting but can be significant in some cases.

**Why the Correct Answer is Right**
Adverse reactions following whole cell pertussis immunization can manifest as local reactions, such as redness, swelling, and pain at the injection site, as well as systemic reactions like fever, excessive crying, and irritability. The systemic reactions are thought to be mediated by the immune response to the inactivated bacteria, which can cause a release of pro-inflammatory cytokines and other mediators. The local reactions are likely due to the direct response of the immune system to the vaccine antigens. Excessive crying, in particular, is a well-documented side effect of whole cell pertussis vaccines, although its exact mechanism is not fully understood.

**Why Each Wrong Option is Incorrect**
* **Option A:** Fever is indeed a possible adverse reaction to whole cell pertussis immunization, but it is not the only one, and the question asks for all possible reactions.
* **Option B:** Excessive crying is a documented side effect of whole cell pertussis vaccines, but again, there are other adverse reactions as well.
* **Option C:** Local swelling is a possible adverse reaction to whole cell pertussis immunization, but it is not the only one, and the question asks for all possible reactions.

**Clinical Pearl / High-Yield Fact**
The whole cell pertussis vaccine has largely been replaced by acellular pertussis vaccines in many countries due to concerns about the risk of adverse reactions and the development of pertussis toxin antibodies, which can interfere with the immune response to future vaccinations.

**✓ Correct Answer: D. All of above**