**Core Concept**
Immune complex mediated hypersensitivity reactions are a type of Type III hypersensitivity reaction, characterized by the formation of antigen-antibody complexes (immune complexes) that deposit in tissues, triggering an inflammatory response.

**Why the Correct Answer is Right**
In immune complex mediated hypersensitivity reactions, antibodies bind to antigens, forming complexes that are too large to be cleared by the reticuloendothelial system. These complexes then deposit in tissues, such as the kidneys, lungs, and skin, leading to activation of the complement system and recruitment of inflammatory cells, resulting in tissue damage and clinical manifestations. This type of reaction is often seen in conditions such as systemic lupus erythematosus (SLE) and serum sickness.

**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it refers to a Type IV hypersensitivity reaction, which is mediated by T cells rather than immune complexes.
**Option B:** This option is incorrect because it refers to a Type II hypersensitivity reaction, which involves antibodies binding to cell surface antigens, not immune complexes.
**Option C:** This option is incorrect because it refers to a Type I hypersensitivity reaction, which involves IgE antibodies and mast cell degranulation, not immune complexes.

**Clinical Pearl / High-Yield Fact**
In immune complex mediated hypersensitivity reactions, the kidneys are often involved, leading to glomerulonephritis, and the skin is also commonly affected, resulting in skin lesions and rashes. This is why patients with conditions like SLE often present with renal and dermatological manifestations.

**Correct Answer: D. Immune complex mediated hypersensitivity reaction is characterized by the formation of antigen-antibody complexes that deposit in tissues, leading to inflammation and tissue damage.**