Imipenem is combined with cilastatin to
Correct Answer: Cilastatin prevents degradation of imipenem in kidney
Description: Imipenems rapidly inactivated by renal dehydropeptidase I, so it is combined with cilastatin, an inhibitor of this enzyme. Cilastatin, a reversible inhibitor of dehydropeptidase, increases the half life of imipenem and also inhibits the formation of nephrotoxic metabolite. Meropenem, doripenem and eapenemare not metabolized by renal dehydropeptidase
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