Medical MCQ - Imipenem, a newer antibiotic with a broad antibacterial spectrum, is coadministered with cilastin because -

Imipenem, a newer antibiotic with a broad antibacterial spectrum, is coadministered with cilastin because –

The combination of these antibiotics is Synergistic against Pseudomonas species

Cilastin aids the gastrointestinal absorption of the active moiety, imipenem

Cilastin inhibits a Beta-lactamase that destroys imipenem

Cilastin inhibits an enzyme in the kidney that destroys imipenem

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Correct Answer:

Cilastin inhibits an enzyme in the kidney that destroys imipenem

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