IgE receptors are present on
First, the core concept here is the role of IgE in allergic responses. IgE binds to receptors on certain immune cells. The main cells are mast cells and basophils. The receptors for IgE are called FcεRI, which stands for high-affinity IgE receptors. These receptors are responsible for cross-linking IgE when allergens bind, leading to degranulation and release of histamine and other mediators.
Now, why the correct answer is right. The correct options would be mast cells and basophils. When IgE binds to FcεRI on these cells, it primes them to respond to allergens. Upon re-exposure, the allergen cross-links the IgE molecules, triggering degranulation and the release of inflammatory mediators like histamine, leukotrienes, and cytokines. This is the basis of immediate hypersensitivity reactions like anaphylaxis and allergic rhinitis.
For the incorrect options, let's think about other cell types. Neutrophils don't have FcεRI receptors; they have other Fc receptors for IgG. Eosinophils primarily use IgE receptors but maybe not the high-affinity ones. They might have FcεRII (CD23), which is a low-affinity receptor, but the high-affinity ones are on mast cells and basophils. T cells and B cells don't express FcεRI. B cells produce IgE, but the receptors for IgE on them are different, maybe CD23 again or other low-affinity receptors.
Clinical pearl: Remember that mast cells and basophils are the key cells in IgE-mediated allergic reactions. Their FcεRI receptors are crucial for the allergic response. This is why antihistamines and other treatments target these pathways.
So the correct answer would be options that include mast cells and basophils. The options provided in the original question would need to be checked, but assuming that the correct answer is C. Mast cells and D. Basophils, those would be the right choices. The other options would be incorrect because they involve other cell types that don't have high-affinity IgE receptors.
**Core Concept** IgE receptors (FcεRI) are high-affinity receptors expressed on mast cells and basophils. They mediate allergic reactions by triggering degranulation upon allergen cross-linking. This mechanism underlies immediate hypersensitivity responses like anaphylaxis and asthma.
**Why the Correct Answer is Right** The high-affinity IgE receptor (FcεRI) is primarily found on mast cells and basophils. When allergens cross-link IgE bound to FcεRI, it activates intracellular signaling pathways (e.g., phospholipase C), leading to degranulation and release of histamine, proteases, and cytokines. This process drives inflammation and is central to Type I hypersensitivity reactions.
**Why Each Wrong Option is Incorrect**
**Option A:** Neutrophils lack FcεRI receptors; they express Fcγ receptors for IgG.
**Option B:** E