**Core Concept**
IgE is a type of antibody involved in the mediation of allergic reactions. It binds to specific receptors on the surface of immune cells, leading to the release of histamine and other chemical mediators. The binding of IgE to these cells triggers a cascade of events resulting in allergic inflammation.

**Why the Correct Answer is Right**
IgE binds specifically to the high-affinity IgE receptor (FcεRI) on the surface of mast cells and basophils. This receptor is composed of an α subunit that binds IgE, and β and γ subunits that are involved in signal transduction. When IgE binds to FcεRI, it becomes sensitized to subsequent exposure to allergens, leading to the activation of mast cells and the release of histamine and other mediators. This process is central to the pathophysiology of allergic reactions.

**Why Each Wrong Option is Incorrect**
**Option A:** IgE does not bind to the high-affinity IgG receptor (FcγRI), which is involved in the binding of IgG antibodies to immune cells.
**Option B:** IgE does not bind to the low-affinity IgE receptor (FcεRII), which is involved in the binding of IgE to some immune cells but has a lower affinity than FcεRI.
**Option C:** IgE does not bind to the high-affinity IgA receptor (FcαRI), which is involved in the binding of IgA antibodies to immune cells.

**Clinical Pearl / High-Yield Fact**
Mast cells and basophils are the primary immune cells involved in allergic reactions, and their activation by IgE-bound allergens is a key step in the development of allergic inflammation. Understanding the role of IgE and its receptors is essential for the diagnosis and treatment of allergic diseases.

**Correct Answer: C. Basophils and mast cells.**