Ans. is 'c' i.e., limb defect o When CVS performed at less than Id weeks of gestation there is a high incidence of limb reduction defects.Chorionic villus sampling (CVS)o Performed for prenatal diagnosis of genetic disorderso It is carried out transcervically between 10 - 12 weeks and transabdominally from 10 weeks to term.o Complications - fetal loss, oromandibular or limb deformities, and vaginal bleedingo When CKS performed at less than 10 weeks of gestation there is a high incidence of limb reduction defects.