(C) Zidovudine (AZT) prophylaxis to health care worker # Treatment of Needle stick injury of a health care worker: Immediately clean the contaminated area by washing under running water# Post exposure prophylaxis should be started within 1 hour of injury Zidovudine 250 mg BD- for 1 month Lamivudine 150 mg BD-- Indinavir 800 mg TID- > Hepatitis prophylaxis should also be given> HIV test should be repeated approx 12 wks after contaminated determine whether seroconversion has occured.> Post exposure prophylaxis with zidovudine and lamivudine is necessary.> Wound should be cleansed immediately and antiseptic applied> Postexposure prophylaxis 2 nucleoside analonuge reverse transcriptase inhibitor X 4 week or combination of 2 nucleoside analogue reverse transcriptase Inhibitor + a protease inhibitor for 4 weeks