**Core Concept**
Retinoblastoma is a malignant tumor of the retina, primarily affecting children, and bilateral retinoblastoma (B/L) is a more aggressive form with a higher risk of metastasis and mortality. The ideal treatment aims to preserve vision and prevent tumor spread while minimizing long-term effects.

**Why the Correct Answer is Right**
The current standard of care for B/L retinoblastoma involves a combination of chemotherapy, focal therapy (such as laser photocoagulation, cryotherapy, or brachytherapy), and radiation therapy. Chemotherapy is used to shrink the tumors, making them easier to manage with focal therapies. In some cases, enucleation (removal of the eye) may be necessary to control the tumor. The goal is to achieve local control while preserving as much vision as possible.

**Why Each Wrong Option is Incorrect**
* **Option A:** This option is incorrect because it does not address the need for chemotherapy and focal therapy in B/L retinoblastoma.
* **Option B:** This option is incorrect because it focuses solely on radiation therapy, which can have significant long-term effects, including secondary malignancies.
* **Option C:** This option is incorrect because it prioritizes enucleation over other treatment modalities, which may not be necessary in all cases.

**Clinical Pearl / High-Yield Fact**
When treating B/L retinoblastoma, it is essential to consider the tumor's genetic makeup, as patients with germline mutations may require more aggressive treatment to prevent metastasis.

**Correct Answer:** C. Enucleation