Hypothyroidism is caused by?
Correct Answer: All of the above
Description: ANSWER: (D) All of the aboveREF: Harrison's Principles of Internal Medicine 17th ed-chapter 335Causes of HypothyroidismPRIMARYAutoimmune hypothyroidism: Hashimoto's thyroiditis, atrophic thyroiditisIatrogenic: Iodine-131 treatment, subtotal or total thyroidectomy, external irradiation of neck for lymphoma or cancerDrugs: iodine excess (including iodine-containing contrast media and amiodarone), lithium, antithyroid drugs, p-aminosalicyclic acid, interferon- and other cytokines, aminoglutethimide Congenital hypothyroidism: absent or ectopic thyroid gland, dyshormonogenesis, TSH-R mutation Iodine deficiencyInfiltrative disorders: Amyloidosis, Sarcoidosis, hemochromatosis, scleroderma, cystinosis, Riedel's thyroiditis, Overexpression of type 3 deoiodinase in infantile hemangioma TRANSIENTSilent thyroiditis, including postpartum thyroiditisSubacute thyroiditisWithdrawal of thyroxine treatment in individuals with an intact thyroidAfter 1311 treatment or subtotal thyroidectomy for Graves' diseaseSECONDARYHypopituitarism: tumors, pituitary surgery or irradiation, infiltrative disorders, Sheehan's syndrome, trauma, genetic forms of combined pituitary hormone deficiencies Isolated TSH deficiency or inactivity Bexarotene treatmentHypothalamic disease: tumors, trauma, infiltrative disorders, idiopathic
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