Drug capable of causing ocular hypotension with apnoea in infants is
**Core Concept**
The question is testing the knowledge of a specific medication that can cause ocular hypotension (decreased intraocular pressure) and apnea (cessation of breathing) in infants. This is a critical side effect that requires careful consideration in pediatric patients.
**Why the Correct Answer is Right**
The correct answer is **Timolol**, a non-selective beta-blocker that can cause ocular hypotension by reducing aqueous humor production in the eye. In infants, Timolol can also cause apnea due to its systemic effects on the respiratory system. This is because beta-2 adrenergic receptors in the lungs are responsible for bronchodilation and regulating breathing rate. When these receptors are blocked by Timolol, it can lead to apnea.
**Why Each Wrong Option is Incorrect**
* **Option A:** **Atropine** is an anticholinergic medication that can cause mydriasis (pupil dilation) and cycloplegia (paralysis of the ciliary muscles), but it is not associated with ocular hypotension or apnea.
* **Option B:** **Pilocarpine** is a muscarinic receptor agonist that can cause miosis (pupil constriction) and increased intraocular pressure, which is the opposite of ocular hypotension.
* **Option C:** **Cyclopentolate** is an anticholinergic medication that can cause mydriasis and cycloplegia, but it is not associated with ocular hypotension or apnea.
**Clinical Pearl / High-Yield Fact**
It's essential to remember that non-selective beta-blockers like Timolol can have significant systemic effects in infants, including apnea. Always consider the potential risks and benefits of using these medications in pediatric patients.
**Correct Answer: C. Timolol**