**Core Concept**
Hypokalemic paralysis is a life-threatening condition characterized by muscle weakness, paralysis, and respiratory failure due to severe potassium depletion. It is often associated with hormonal imbalances, particularly those involving the renin-angiotensin-aldosterone system (RAAS) and the hypothalamic-pituitary-adrenal axis.
**Why the Correct Answer is Right**
The correct answer is a medication that acts as a mineralocorticoid receptor antagonist, thereby blocking the effects of aldosterone, a hormone that promotes potassium excretion and sodium retention. This leads to an increase in potassium levels and a decrease in sodium levels, resulting in hypokalemic paralysis. The medication in question is a non-selective mineralocorticoid receptor antagonist that also has some activity as a glucocorticoid receptor antagonist.
**Why Each Wrong Option is Incorrect**
**Option A:** Not a known cause of hypokalemic paralysis.
**Option B:** Actually a medication that can cause hyperkalemia by blocking the renin-angiotensin-aldosterone system.
**Option C:** Not a known cause of hypokalemic paralysis, and its primary mechanism of action is not related to potassium levels.
**Clinical Pearl / High-Yield Fact**
Hypokalemic paralysis is a medical emergency that requires prompt treatment with potassium replacement and addressing the underlying cause, which may involve medications like the one in question or hormonal imbalances.
**Correct Answer:** C. Spironolactone
Free Medical MCQs Β· NEET PG Β· USMLE Β· AIIMS
Access thousands of free MCQs, ebooks and daily exams.
By signing in you agree to our Privacy Policy.