**Core Concept**
The patient's 47 XXY karyotype indicates a sex chromosome aneuploidy, specifically a condition known as Klinefelter syndrome. This condition is characterized by an extra X chromosome in males, leading to various physical and hormonal abnormalities.
**Why the Correct Answer is Right**
Klinefelter syndrome is associated with hypogonadism due to impaired testicular function. The extra X chromosome disrupts the balance of sex hormones, resulting in decreased testosterone production and elevated estrogen levels. This hormonal imbalance leads to the characteristic features of hypogonadism, including small testes, infertility, and reduced facial and body hair. The testes often produce elevated levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), further indicating testicular dysfunction.
**Why Each Wrong Option is Incorrect**
* **Option A:** This option is incorrect because it does not match the patient's 47 XXY karyotype, which is a hallmark of Klinefelter syndrome.
* **Option B:** This option is incorrect because it refers to a different sex chromosome aneuploidy, 47 XYY, which is associated with tall stature, infertility, and an increased risk of learning disabilities, but not hypogonadism.
* **Option D:** This option is incorrect because it refers to a different condition, Kallmann syndrome, which is characterized by delayed puberty and anosmia (loss of smell), but not the specific 47 XXY karyotype.
**Clinical Pearl / High-Yield Fact**
Klinefelter syndrome is a common sex chromosome aneuploidy, affecting approximately 1 in 650 males. It is essential to recognize the characteristic features of hypogonadism and the associated hormonal imbalances in patients with this condition.
**Correct Answer: C. Klinefelter syndrome**
Free Medical MCQs Β· NEET PG Β· USMLE Β· AIIMS
Access thousands of free MCQs, ebooks and daily exams.
By signing in you agree to our Privacy Policy.