Deficiency of which element can lead to syndrome of growth failure, anaemia and hypogonadism ?
**Core Concept**
The question refers to a specific nutritional deficiency that affects growth, hematopoiesis, and reproductive function. This condition is characterized by impaired growth, anemia, and hypogonadism, indicating a multifaceted impact on various bodily systems.
**Why the Correct Answer is Right**
The correct answer is related to the deficiency of Zinc (Zn). Zinc plays a crucial role in growth and development, DNA synthesis, and gene expression. It is essential for the proper functioning of various enzymes, including those involved in protein synthesis, carbohydrate metabolism, and the regulation of cell growth. Zinc also plays a critical role in the maintenance of immune function, wound healing, and the regulation of reproductive hormones. The deficiency of zinc can lead to impaired growth, anemia, hypogonadism, and impaired immune function.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because the deficiency of Iron (Fe) primarily affects erythropoiesis, leading to anemia, but it does not cause growth failure or hypogonadism.
**Option B:** This option is incorrect because the deficiency of Vitamin B12 (Cobalamin) affects the synthesis of DNA and the maintenance of the nervous system, but it does not directly cause growth failure or hypogonadism.
**Option C:** This option is incorrect because the deficiency of Folate affects the synthesis of DNA and the maintenance of the nervous system, but it does not directly cause growth failure or hypogonadism.
**Clinical Pearl / High-Yield Fact**
Zinc deficiency can be caused by inadequate dietary intake, increased excretion, or impaired absorption, and it can be treated with zinc supplements. It is essential to note that zinc deficiency can also be associated with impaired wound healing, delayed puberty, and increased susceptibility to infections.
**Correct Answer:** D. Zinc