All of the following cause microcytic hypochromic anaemia, EXCEPT –
**Core Concept**
Microcytic hypochromic anemia is characterized by small (microcytic) and pale (hypochromic) red blood cells. This type of anemia is typically caused by a deficiency in iron, thalassemia, or other conditions that affect hemoglobin synthesis.
**Why the Correct Answer is Right**
Microcytic hypochromic anemia is commonly associated with conditions that impair hemoglobin production, such as iron deficiency anemia, thalassemia, and sideroblastic anemia. These conditions can lead to a decrease in the production of hemoglobin, resulting in small and pale red blood cells.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it is a cause of microcytic hypochromic anemia. Iron deficiency anemia, for example, is characterized by decreased iron availability, leading to reduced hemoglobin production and resulting in microcytic hypochromic anemia.
**Option B:** This option is incorrect because it is a cause of normocytic anemia. Normocytic anemia is characterized by red blood cells of normal size and hemoglobin content. Conditions such as anemia of chronic disease, for example, typically result in normocytic anemia.
**Option C:** This option is incorrect because it is a cause of macrocytic anemia. Macrocytic anemia is characterized by large red blood cells with reduced hemoglobin content. Conditions such as vitamin B12 deficiency, for example, typically result in macrocytic anemia.
**Option D:** This option is incorrect because it is a cause of microcytic hypochromic anemia. Thalassemia, for example, is a genetic disorder that affects hemoglobin synthesis, leading to microcytic hypochromic anemia.
**Clinical Pearl / High-Yield Fact**
When evaluating a patient with anemia, it is essential to consider the size and hemoglobin content of the red blood cells. Microcytic hypochromic anemia typically suggests a problem with hemoglobin synthesis, while normocytic anemia may indicate a problem with red blood cell destruction or production.
**Correct Answer:** B.