**Core Concept**
The question is testing the understanding of the hypocholesterolemic effects of various fatty acids, specifically their ability to lower cholesterol levels in the body. This concept is relevant to the management of hyperlipidemia and cardiovascular disease.
**Why the Correct Answer is Right**
The correct answer is **A. Oleic acid** (C18:1). Oleic acid, a monounsaturated fatty acid, has a pronounced hypocholesterolemic effect. It does so by inhibiting the synthesis of cholesterol in the liver through the suppression of the enzyme HMG-CoA reductase, which is the rate-limiting step in the cholesterol biosynthesis pathway. Additionally, oleic acid increases the clearance of low-density lipoprotein (LDL) cholesterol from the bloodstream.
**Why Each Wrong Option is Incorrect**
**Option B:** Palmitic acid (C16:0) is a saturated fatty acid that actually increases cholesterol levels by stimulating the synthesis of cholesterol in the liver.
**Option C:** Stearic acid (C18:0) is another saturated fatty acid that, like palmitic acid, can raise cholesterol levels by promoting the production of cholesterol in the liver.
**Option D:** Linoleic acid (C18:2) is an omega-6 polyunsaturated fatty acid that, while beneficial in reducing inflammation, does not have a significant hypocholesterolemic effect.
**Clinical Pearl / High-Yield Fact**
Remember that dietary monounsaturated fatty acids, like oleic acid, can help reduce LDL cholesterol levels and improve overall cardiovascular risk profiles. This is a key concept in the management of hyperlipidemia and should be taken into consideration when counseling patients on dietary modifications.
**Correct Answer: A. Oleic acid**
Free Medical MCQs Β· NEET PG Β· USMLE Β· AIIMS
Access thousands of free MCQs, ebooks and daily exams.
By signing in you agree to our Privacy Policy.