The drug of choice for treatment of hyperthyroidism during lactation period is –
**Core Concept**
During lactation, it is crucial to choose an antithyroid medication that effectively controls hyperthyroidism with minimal transfer to breast milk, ensuring the safety of both the mother and the infant. The primary goal is to select a drug that is not significantly excreted into breast milk or has a low risk of causing adverse effects in the infant.
**Why the Correct Answer is Right**
The drug of choice for treating hyperthyroidism during lactation is Propylthiouracil (PTU). PTU is a thionamide that inhibits thyroid hormone synthesis by blocking the enzyme thyroid peroxidase (TPO). This action reduces the production of thyroid hormones, thereby controlling hyperthyroidism. Importantly, PTU has a low risk of being excreted into breast milk, making it a safer option for lactating women.
**Why Each Wrong Option is Incorrect**
**Option A:** Methimazole is another thionamide, but it is not the preferred choice during lactation because it is more likely to be excreted into breast milk, potentially causing neonatal hypothyroidism.
**Option B:** Radioactive iodine is contraindicated during lactation due to the risk of radioactive iodine being secreted into breast milk and potentially harming the infant.
**Option C:** Iodine is not effective in the long-term management of hyperthyroidism, especially during lactation, as it may exacerbate the condition and is not suitable for controlling thyroid hormone production.
**Clinical Pearl / High-Yield Fact**
When treating hyperthyroidism during lactation, it is essential to choose an antithyroid medication with a low risk of transfer to breast milk, such as Propylthiouracil (PTU), to ensure the safety of both the mother and the infant.
**Correct Answer:** C. Propylthiouracil (PTU)