**Core Concept**
The Wheal and Flare reaction is a type of immediate hypersensitivity reaction that occurs due to the release of histamine and other mediators from mast cells. This reaction is a classic example of an allergic response, typically seen in individuals with allergies or asthma.

**Why the Correct Answer is Right**
The Wheal and Flare reaction is a manifestation of Type I hypersensitivity, also known as anaphylactic hypersensitivity. This type of hypersensitivity is mediated by IgE antibodies, which bind to mast cells and basophils. When an allergen binds to the IgE antibody, it triggers the release of histamine and other chemical mediators, leading to increased vascular permeability, smooth muscle contraction, and vasodilation. The resulting Wheal and Flare reaction is characterized by a localized area of edema (Wheal) and increased blood flow (Flare).

**Why Each Wrong Option is Incorrect**
**Option A:** Type II hypersensitivity is incorrect because it involves IgG or IgM antibodies targeting cell surface or matrix antigens, leading to cellular damage or destruction.
**Option B:** Type III hypersensitivity is incorrect because it involves immune complex formation and deposition, leading to inflammation and tissue damage.
**Option C:** Type IV hypersensitivity is incorrect because it involves T-cell mediated reactions, often delayed in onset and characterized by cell-mediated immunity.

**Clinical Pearl / High-Yield Fact**
Remember that the Wheal and Flare reaction is a classic sign of anaphylactic hypersensitivity, and it can occur within minutes of exposure to an allergen. This reaction is often seen in individuals with allergies to peanuts, shellfish, or insect stings.

**Correct Answer:** D. Type I