**Core Concept**
Von Gierke's disease, also known as Glycogen Storage Disease Type I (GSD I), is an inherited disorder characterized by the deficiency of glucose-6-phosphatase enzyme, leading to impaired glycogen breakdown and accumulation of glycogen in the liver. This results in hypoglycemia, hepatomegaly, and other metabolic disturbances.

**Why the Correct Answer is Right**
The correct answer is Von Gierke's disease because it is the most common form of glycogen storage disease, and the symptoms described in the question are classic for this condition. The deficiency of glucose-6-phosphatase enzyme in Von Gierke's disease impairs the conversion of glycogen to glucose, leading to accumulation of glycogen in the liver and subsequent release of fatty acids and ketone bodies, resulting in hyperlipidemia and acidosis. Additionally, the impaired glycogen breakdown leads to frequent episodes of hypoglycemia.

**Why Each Wrong Option is Incorrect**
**Option B:** Cori's disease, also known as Glycogen Storage Disease Type III (GSD III), is caused by a deficiency of the debranching enzyme, which breaks down glycogen branches. While Cori's disease also presents with hepatomegaly and hypoglycemia, it typically does not present with hyperlipidemia and acidosis.

**Option C:** Pompe's disease, also known as Glycogen Storage Disease Type II (GSD II), is caused by a deficiency of the acid alpha-glucosidase enzyme, which breaks down glycogen in lysosomes. Pompe's disease typically presents with muscle weakness, cardiomegaly, and respiratory failure, rather than the metabolic disturbances described.

**Option D:** All of the above is incorrect because the question describes a specific clinical presentation that is most consistent with Von Gierke's disease.

**Clinical Pearl / High-Yield Fact**
It's essential to remember that Von Gierke's disease is characterized by a "hypoglycemic hyperglycemic paradox," where patients have episodes of hypoglycemia despite having high blood glucose levels due to the impaired glycogen breakdown and subsequent release of glucose into the bloodstream.

**Correct Answer Line**
✓ Correct Answer: A. Von Gierke's disease.