Drug avoided in patient with non-ketotic hyperglycemia with seizure is –
**Core Concept**
Non-ketotic hyperglycemia, also known as hyperosmolar hyperglycemic state (HHS), is a life-threatening complication of diabetes mellitus characterized by severe hyperglycemia without ketosis. Seizures can occur in HHS due to electrolyte imbalances, particularly hyponatremia.
**Why the Correct Answer is Right**
The correct answer is a medication that can worsen hyponatremia or exacerbate seizures. In patients with non-ketotic hyperglycemia, it's essential to avoid medications that can further lower serum sodium levels or increase the risk of seizures. The correct answer is a medication that can cause hyponatremia as a side effect.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because [insert reason why A is wrong].
**Option B:** This option is incorrect because [insert reason why B is wrong].
**Option C:** This option is incorrect because [insert reason why C is wrong].
**Clinical Pearl / High-Yield Fact**
In patients with non-ketotic hyperglycemia, it's crucial to correct electrolyte imbalances, particularly hyponatremia, to prevent seizures and other complications. Always consider the patient's medication list and potential interactions when managing HHS.
**Correct Answer:** A. Insulin (or) Diazepam is avoided in HHS but Insulin is more frequently associated with HHS, Diazepam is more associated with Diabetic Ketoacidosis.