Hypercoagulability due to defective factor V gene is called-
**Core Concept**
The question tests the understanding of hypercoagulability states, specifically those related to genetic defects in coagulation factors. **Factor V Leiden** is a key concept here, involving a mutation in the factor V gene that leads to thrombophilia.
**Why the Correct Answer is Right**
Factor V Leiden is a result of a point mutation in the factor V gene, leading to an alteration in the factor V protein that makes it resistant to inactivation by activated protein C (APC). This results in an increased tendency for blood to clot, as the mutated factor V continues to participate in the coagulation cascade unchecked.
**Why Each Wrong Option is Incorrect**
**Option A:** This is not directly related to the specific genetic defect causing hypercoagulability due to factor V.
**Option B:** Similarly, this option does not accurately describe the condition related to the defective factor V gene.
**Option D:** This option is incorrect as it does not specify the condition associated with the factor V gene mutation.
**Clinical Pearl / High-Yield Fact**
Factor V Leiden is the most common inherited cause of hypercoagulability, significantly increasing the risk of deep vein thrombosis and pulmonary embolism. Recognizing this condition is crucial for appropriate management and prevention of thrombotic events.
**Correct Answer:** Factor V Leiden.