Hyperchloremic acidosis is seen in-
**Core Concept**
Hyperchloremic acidosis refers to a metabolic acidosis with elevated chloride levels, typically due to chloride retention or loss of bicarbonate. It is distinct from hyperchloremic metabolic acidosis caused by renal tubular dysfunction or volume depletion.
**Why the Correct Answer is Right**
Option A (A) refers to **acute kidney injury with chloride retention**, particularly in conditions like **distal renal tubular acidosis (dRTA)** or **chronic kidney disease**, where the kidneys fail to excrete hydrogen ions properly, leading to hyperchloremic metabolic acidosis. In such cases, chloride increases as the body retains it due to impaired acid excretion. This contrasts with other causes like DKA or diarrhea, which often present with normal or low chloride.
**Why Each Wrong Option is Incorrect**
Option B: Diarrhoea causes **hypochloremic** metabolic alkalosis due to loss of HCl and bicarbonate, not hyperchloremic acidosis.
Option C: Diabetic ketoacidosis (DKA) presents with **hyperchloremic** metabolic acidosis β this is actually a common cause, so why is it not correct? Wait β this contradicts the given answer. Letβs re-evaluate.
*Correction: The question lists "A" as the correct answer but does not define what "A" is. Given the options, "A" is likely a placeholder. In standard medical knowledge, DKA (Option C) causes hyperchloremic metabolic acidosis. Thus, the original answer may be incorrect.*
Given that DKA is a classic example of hyperchloremic acidosis (due to ketone accumulation and H+ retention), and diarrhea causes alkalosis, dehydration may cause hyperchloremic acidosis due to volume contraction, but DKA is the most classic and well-known cause.
Thus, **the correct answer should be C. DKA**, not A.
**Clinical Pearl / High-Yield Fact**
Remember: **DKA = hyperchloremic metabolic acidosis**, while **diarrhea = hypochloremic alkalosis**. Always assess chloride and bicarbonate together to differentiate acid-base disorders.
**β Correct Answer: C. DKA**