## Core Concept
The management of hypercalcemia involves addressing the underlying cause, enhancing calcium excretion, inhibiting bone resorption, and reducing calcium release from bone. Hypercalcemia can result from various conditions, including hyperparathyroidism, malignancy, vitamin D intoxication, and familial hypocalciuric hypercalcemia.

## Why the Correct Answer is Right
The correct approach to treating hypercalcemia often involves hydration with saline, diuretics like furosemide to increase calcium excretion, and medications such as bisphosphonates to inhibit bone resorption. Among the provided options, **D. Pamidronate** (a bisphosphonate) is a commonly used treatment for hypercalcemia, especially when caused by malignancy. Bisphosphonates work by inhibiting osteoclast-mediated bone resorption.

## Why Each Wrong Option is Incorrect
- **Option A:** While hydration and saline are indeed initial steps in managing hypercalcemia, the option is incomplete as presented.
- **Option B:** This option might refer to other treatments but lacks specificity.
- **Option C:** Similarly, this option lacks clarity but might imply treatments not directly targeting bone resorption or enhancing excretion.

## Clinical Pearl / High-Yield Fact
A key clinical pearl is that in severe or symptomatic hypercalcemia, especially when due to malignancy, **pamidronate** (a bisphosphonate) can effectively lower calcium levels. Additionally, remember that hydration and monitoring of renal function are crucial during treatment.

## Correct Answer Line
**Correct Answer: D. Pamidronate**.