Physiology Hypercalcemia associated with malignancy is most often mediated by A Parathyroid hormone (PTH) B Parathyroid hormone related protein (PTHrP) C Interleukin-6 (IL-6) D Calcitonin 💡 Explanation Hypercalcemia associated with malignancy is most often mediated by ✓ Correct Answer: B. Parathyroid hormone related protein (PTHrP)