Physiology Hypercalcemia associated with malignancy is most often mediated by: A Parathyroid hormone (PTH) B Parathyroid hormone related protein (PTHrP) C Interleukin - 6 (IL-6). D Calcitonin 💡 Explanation Hypercalcemia associated with malignancy is most often mediated by: ✓ Correct Answer: B. Parathyroid hormone related protein (PTHrP)