Hypeension with hyperkalemia is seen in –
Correct Answer: Gordon's syndrome
Description: GORDON&;S syndrome with identified mutations of WNK1 and WNK4 (members of a family of serine-threonine kinases) have been shown to cause the rare familial autosomal dominant disease, Gordon&;s syndrome (also known as pseudohypoaldosteronism type II). Wild-type WNK1 and WNK4 inhibit the thiazide-sensitive Na-Cl co-transpoer in the distal tubule. Mutations of these proteins are associated with gain of function and increased co-transpoer activity, excessive chloride and sodium reabsorption, and volume expansion. This syndrome is characterized by sho stature, intellectual impairment, dental abnormalities, muscle weakness, SEVERE HYPEENSION by the third decade of life, low fractional excretion of sodium, normal renal function, hyperchloremic metabolic acidosis, and low renin and aldosterone levels. Hyperkalemia, another hallmark of this syndrome, might be a function of diminished sodium delivery to the coical collecting tubule
Category:
Medicine
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now