## **Core Concept**
Pregnancy-induced hypertension, also known as gestational hypertension or preeclampsia, requires careful management to prevent complications for both mother and fetus. The management involves antihypertensive drugs that are safe for both the mother and the fetus.

## **Why the Correct Answer is Right**
Methyldopa (Option C) is considered a first-line treatment for hypertension in pregnancy. It works centrally by stimulating α2-adrenergic receptors, which decreases sympathetic tone, leading to decreased blood pressure. Methyldopa has a long history of safe use in pregnancy and is often considered the drug of choice due to its efficacy and safety profile for both the mother and the fetus.

## **Why Each Wrong Option is Incorrect**
- **Option A:** Nifedipine, a calcium channel blocker, can be used in pregnancy-induced hypertension but is usually considered after methyldopa or in specific cases. It can cause reflex tachycardia and has a less established safety profile compared to methyldopa.
- **Option B:** Propranolol, a beta-blocker, can be used but is generally avoided in the first trimester due to the risk of growth restriction and other potential fetal side effects. It's not typically the first choice.
- **Option D:** Lisinopril, an ACE inhibitor, is contraindicated in pregnancy due to the risk of fetal renal damage and other severe side effects.

## **Clinical Pearl / High-Yield Fact**
A key point to remember is that methyldopa is often the preferred initial antihypertensive agent in pregnancy due to its safety profile. However, the choice of antihypertensive can depend on other factors such as the presence of preeclampsia, chronic hypertension, or other medical conditions.

## **Correct Answer:** C. Methyldopa.